Serotonin
1A Agonists (Wiki)
Serotonin 1A Agonists such as Buspirone do not cause the sedation that more conventional
anxiolytics cause as well as the
dependence; however, this lack in
sedation may also make the drug less effective than, say,
Benzodiazepines.
Buspirone
(Wiki)
Brand names:
Ansial®, Ansiced®, Anxiron®, Axoren®, Bespar®, BuSpar®,
Buspimen®, Buspinol®, Buspisal®, Narol®, Spitomin®
Formula: C21H31N5O2
Half life: ~ 2 to 3 hours
Single unit dose: Unknown
Recommended outpatient dose: 15mg per day
[Verified]
Maximum outpatient dose: 45mg per day
[Verified]
Buspirone is an anxiolytic drug unrelated to conventional
tranquillisers such as benzodiazepines. In terms of efficacy it is roughly
equal to the benzodiazepine medication diazepam in the treatment of generalised anxiety disorders
but is less effective
than benzodiazepines in general. It is also very useful in
the treatment of anxious depressive illnesses when mixed with SSRI antidepressants in particular. Unusually for an
anxiolytic, buspirone is not sedating and does not interact with
alcohol; it is also thought not to be
addicting. Unfortunately the drug takes several weeks to take effect so
patients are often treated with faster acting
tranquillisers initially. Buspirone should not strictly be mixed
with RIMA or MAOI antidepressants.