Butyrophenones (Wiki)

Butyrophenones are psychiatric drugs aimed primarily at the treatment of psychotic illnesses.


Melperone/Methylperone (Wiki)

Brand names: Buronil®, Burnil®, Eunerpan®
Formula: C16H22FNO
Half life: ~ 3.5 hours
Single unit dose: 100mg per day
Recommended outpatient dose: 300mg per day [Not Verified]
Maximum outpatient dose: Unknown

A Butyrophenone Atypical Antipsychotic.



Indoles (Wiki)

Indole is an aromatic heterocyclic organic compound that can be put into use as a base for psychiatric medications.


Sertindole (Wiki)

Brand names: Serdolect®, Serlect®
Formula: C24H26ClFN4O
Half life: Unknown
Single unit dose: Unknown
Recommended outpatient dose: 12mg per day [Verified]
Maximum outpatient dose: 24mg per day [Verified]

No longer available to the mass market, sertindole was introduced fairly recently before its fall from power in late 1998. Research indicated that the drug was useful in the treatment of anxiety related disorders yet did not have a sedative effect.

Ziprasidone (Wiki)

Brand names: Geodon®, Zeldox®
Formula: C21H21ClN4OS
Half life: ~ 2 to 5 hours (vague figure)
Single unit dose: 20mg per day
Recommended outpatient dose: Unknown
Maximum outpatient dose: 240mg per day [Verified]

The fifth drug of this family to be successfully marketed, ziprasidone is a recent addition to the atypical family and is establishing itself with relative ease. Unlike many drugs, this medication doesn't have an overly obvious or dominant side effect profile - patients react to the medication on a fairly individual basis. Unlike other drugs of the same family, ziprasidone also impacts on the monoamine neurotransmitter noradrenaline; the consequence of this is unknown.

Unfortunately, ziprasidone can cause birth defects and as such should not be administered to pregnant women. The drug can be stimulating or sedative, depending on the patient and as such can cause fatigue or insomnia, again, depending on the patient. The medication tends to cause weight loss, which may be viewed as beneficial.



Other Serotonin Antagonists (Wiki)

Other Serotonin Antagonistic Antipsychotic medications that do not fit into any of the other categories on this site.


Iloperidone (Wiki)

Brand names: Fanapta®, Fiapta®, Zomaril®
Formula: C24H27FN2O4
Half life: Unknown
Single unit dose: Unknown
Recommended outpatient dose: 12mg per day [Highly Questionable]
Maximum outpatient dose: 32mg per day [Highly Questionable]

An investigational Atypical Antipsychotic, Iloperidone is still undergoing trials for clinical usage followng, on the 28th of July, a decision by the US FDA not to make the drug available for public consumption. It acts on both Dopamine and Serotonin receptors, making it a favorable choice against similar competing drugs such as Clozapine and Olanzapine. Therepeutic doses begin at 8mg per day and max out at about 32mg per day. A repeat administration of the drug could also decrease the effects of Hypotension.

Paliperidone (Wiki)

Brand names: Invega®, Semap®
Formula: C23H27N4FO3
Half life: ~ 23 hours
Single unit dose: 6mg per day
Recommended outpatient dose: 6mg per day [Not Verified]
Maximum outpatient dose: 15mg per day [Not Verified]

Approved in 2006 for the treatment of psychotic disorders, paliperidone is in essence a variation on the atypical antipsychotic risperidone.

Perospirone (Wiki)

Brand names: Lullan®
Formula: C23H30N4O2S
Half life: Unknown
Single unit dose: Unknown
Recommended outpatient dose: Unknown
Maximum outpatient dose: Unknown

A 5-HT2 receptor antagonist, Perospirone exhibits extrapyramidal symptoms less often and to a gentler extent than, for example, Haloperidol or Mosapramine.

Risperidone (Wiki)

Brand names: Belivon®, Rispen®, Risperdal®
Formula: C23H27FN4O2
Half life: Unknown
Single unit dose: 0.5mg per day
Recommended outpatient dose: 4mg per day [Verified]
Maximum outpatient dose: 8mg per day [Verified]

Usually regarded as the first line antipsychotic, risperidone is stimulant and sports antidepressive effects as well as the obvious; it is the most prescribed antipsychotic in most of the developed world.

Typical side effects include weight gain, stimulation, anxiety, nausea and/or vomiting, dizziness, tremor, insomnia, drooling and muscle stiffness and/or pain; it also affects the patients libido more often than not.

A word to the wise - the tablets taste foul. Ye be warned...

Zotepine (Wiki)

Brand names: Nipolept®
Formula: C18H18ClNOS
Half life: Unknown
Single unit dose: Unknown
Recommended outpatient dose: 75mg per day [Verified]
Maximum outpatient dose: 300mg per day [Verified]

Novel in that it impacts on the monoamine neurotransmitter noradrenaline, zotepine is especially useful in combatting the negative symptoms of schizophrenia and related psychotic illnesses. The medication does typically cause weight gain and that to an extent that rivals the older typical antipsychotics. It is also sedative, with somnolence being the most common side effect associated with this medication.