Phenothiazines (Wiki)

Phenothiazines are psychiatric drugs aimed primarily at the treatment of psychotic illnesses.


Chlorpromazine (Wiki)

Brand names: Largactil®, Thorazine®
Formula: C17H19ClN2S
Half life: ~ 16 to 30 hours (vague figure)
Single unit dose: 100mg per day
Recommended outpatient dose: 300mg per day [Verified]
Maximum outpatient dose: 1000mg per day [Verified]

This drug is an Aliphatic Compund.

The very first antipsychotic drug to be released (initially marketed as an antiemetic and/or an antihistamine until its therapeutic benefits were noted, leading to a release in 1954), chlorpromazine is a sedative drug with anxiolytic properties, making it a good drug for agitated patients. The drug also has a mild antidepressive profile but unfortunately often leads to weight gain, sexual problems and a lowered blood pressure. Its sedative properties apparently reduce over time as patients often build up an immunity to it.

Fluphenazine (Wiki)

Brand names: Modecate®, Prolixin Decanoate®, Dapotum D®, Anatensol®, Fludecate®, Sinqualone Deconoate®, Dapotum Injektion®, Flunanthate®, Moditen Enanthate Injection®, Sinqualone Enanthate®, Prolixin®, Permitil®, Dapotum®, Lyogen®, Moditen®, Omca®, Sediten®, Selecten®, Sevinol®, Sinqualone®, Trancin®
Formula: C22H26F3N3OS
Half life: ~ 15 to 30 hours (vague figure)
Single unit dose: 2mg per day
Recommended outpatient dose: 5mg per day [Verified]
Maximum outpatient dose: 20mg per day [Verified]

This drug is a Piperazine.

An extremely potent drug, fluphenazine is a difficult drug to administer as the low doses leave little room for manoeuvre; it is approximately 60 times more concentrated than the drug chlorpromazine of the same class. It is, alongside the drug haloperidol of the same class, the most likely drug to cause neuroleptic malignant syndrome (NMS).

Levomepromazine (Methotrimeprazine) (Wiki)

Brand names: Levoprome®, Neurocil®, Nozinan®
Formula: C19H24N2OS
Half life: ~ 20 hours
Single unit dose: Unknown
Recommended outpatient dose: 200mg per day [Verified]
Maximum outpatient dose: 1g per day [Verified]

This drug is an Aliphatic Compund.

This drug is a low potent antipsychotic, roughly half the potency of chlorpromazine. It is not, at the time of writing, available in the USA but is available in Europe and Canada. It can effectively be used to combat psychotic illnesses, the manic phases of bipolar disorder and agitated depressive illnesses. It is heavily sedative and as such can also be used to treat insomnia, where the dose range should be 25mg to 50 mg a few hours before bed. Unfortunately, weight gain is a prominent side effect. Caffeine should be avoided.

Mesoridazine (Wiki)

Brand names: Serentil®
Formula: C21H26N2OS2
Half life: ~ 36 hours
Single unit dose: 50mg per day
Recommended outpatient dose: 150mg per day [Not Verified]
Maximum outpatient dose: 400mg per day [Not Verified]

This drug is a Piperidine.

This drug may also be used in the treatment of alcoholism, neurological illnesses and psychoneuroses.

Perphenazine (Wiki)

Brand names: Etrafon®, Minitran®, Trilafon®
Formula: C21H26ClN3OS
Half life: ~ 10 hours
Single unit dose: 10mg per day
Recommended outpatient dose: 12mg per day [Verified]
Maximum outpatient dose: 24mg per day [Verified]

This drug is a Piperazine.

Between 10 and 15 times more potent than Chlorpromazine, Perphenazine is still in active use at the time of writing; its side effect profile and frequency is similar to that of another typical antipsychotic, Haloperidol.

The medication is sedative and as such is used to treat patients suffering from a manic episode or more general agitation; it is especially useful (in high doses) in the treatment of febrile catatonia, a potentially fatal illness. To this end, Perphenazine can be used alongside electro-convulsive therapy (ECT).

Prochlorperazine (Wiki)

This drug is a Piperazine.

Brand names: Buccastem®, Compazine®, Stemetil®
Formula: C20H24N3ClS
Half life: ~ 4 to 8 hours (vague figure)
Single unit dose: 5mg per day
Recommended outpatient dose: 25mg per day [Verified]
Maximum outpatient dose: 100mg per day [Verified]

Now more frequently used to treat nausea and vertigo, prochlorperazine is thought to be as much as twenty times more potent than the drug chlorpromazine of the same class.

Promazine (Wiki)

Brand names: Sparine®
Formula: C17H20N2S
Half life: Unknown
Single unit dose: Unknown
Recommended outpatient dose: 400mg per day [Verified]
Maximum outpatient dose: 800mg per day [Verified]

This drug is an Aliphatic Compund.

No current data.

Thioridazine (Wiki)

Brand names: Mellaril®
Formula: C21H26N2S2
Half life: ~ 7 to 13 hours
Single unit dose: 100mg per day
Recommended outpatient dose: 300mg per day [Not Verified]
Maximum outpatient dose: 800mg per day [Not Verified]

This drug is a Piperidine.

As with the atypical antipsychotic clozapine, thioridazine triggers extrapyramidal side effects in comparatively few cases. Additionally, it seems to have mild antidepressant qualities, a feature that in most cases is desirable. It is also worth mentioning that thioridazine kills off a modern treatment resistant superbug MRSA.

This medication is, more often than not, sedative and as such the most common side effects are drowsiness, fatigue and dizziness. Unfortunately, the drug has a comparatively high incidence rate of sexual side effects.

Trifluoperazine (Wiki)

Brand names: Eskazine®, Eskazinyl®, Jatroneural®, Modalina®, Stelazine®, Terfluzine®
Formula: C21H24F3N3S
Half life: ~ 24 hours
Single unit dose: 5mg per day
Recommended outpatient dose: 10mg per day [Verified]
Maximum outpatient dose: 40mg per day [Highly Questionable]

This drug is a Piperazine.

Approximately twenty times more potent than chlorpromazine, trifluoperazine is a typical antipsychotic that is also used to combat anxiety and more specifically panic attacks; for this, a couple of milligrams when needed usually suffices. Although regarded as a gold standard antipsychotic, it is less frequently used at the time of writing in favour of more modern antipsychotics that exhibit fewer side effects, in particular tardive dyskinesia which can occur in up to 4% of patients treated with trifluoperazine.

Triflupromazine (Wiki)

Brand names: Adazine®, Fluopromazine®, Psyquil®, Siquil®, Vesprin®
Formula: C18H19F3N2S
Half life: Unknown
Single unit dose: Unknown
Recommended outpatient dose: Unknown
Maximum outpatient dose: Unknown

This drug is an Aliphatic Compund.

No current data.